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General Information

Document Type:MOD
Posted Date:Aug 06, 2018
Category: Research and Development
Set Aside:N/A

Contracting Office Address

Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Office of Acquisitions, 5601 Fishers Lane, 3rd Floor, MSC 9821, Bethesda, Maryland, 20892, United States


Attachment - PHS-2019-1 - Rev. 8.6.18 Amendment No. 1 - The purpose of this amendment is to add a new Topic, and to revise the title of another Topic. The National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) are soliciting proposals from small business concerns that possess the research and development (R&D) expertise to conduct innovative research that will contribute toward NIH or CDC mission needs and Small Business Innovation Research (SBIR) program objectives. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES (DHHS), THE NATIONAL INSTITUTES OF HEALTH (NIH) AND THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) SMALL BUSINESS INNOVATIVE RESEARCH (SBIR) PROGRAM SOLICITATION PHS-2019-1 is anticipated to be made available on or around July 18, 2018, through both FedBizOpps.gov and the NIH Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) funding web page at https://sbir.nih.gov/funding. This solicitation is anticipated to have a closing date of October 22, 2018 for receipt of proposal. The purposes of the SBIR program are to: (a) stimulate technological innovation; (b) strengthen the role of small business in meeting Federal research/research & development (R/R&D) needs; (c) foster and encourage participation by socially and economically disadvantaged small business concerns and women-owned business concerns; and (d) increase private sector commercialization of innovations derived from Federal R/R&D, thereby increasing competition, productivity and economic growth. For purposes of the SBIR program, a small business concern is any business concern that, on the date of award, (1) is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor; (2) is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except that where the form is a joint venture, there must be less than 50 percent participation by foreign business entities in the joint venture; (3) more than 50% directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States), other business concerns (each of which is more than 50% directly owned and controlled by individuals who are citizens or permanent resident aliens of the United States), or any combination of these; OR more than 50% owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these. No single venture capital operating company, hedge fund, or private equity firm may own more than 50% of the concern; AND, (4) has, including its affiliates, no more than 500 employees.* * Note : This size standard is established by law for the SBIR program, regardless of the NAICS Code assigned. See 13 C.F.R. § 121.702. THE FOLLOWING RESEARCH TOPICS ARE ANTICIPATED TO BE INCLUDED IN SBIR CONTRACT SOLICITATION PHS-2019-1 NATIONAL INSTITUTES OF HEALTH (NIH) NATIONAL CENTER FOR ADVANCING TRANSLATIONS SCIENCES (NCATS): - Synthetic Technologies for Advancement of Research and Therapeutics (START) - Universal Medium/Blood Mimetic for Use in Integrated Organs-on-Chips - Non-PDMS Biocompatible Alternatives for Organs-On-Chips NATIONAL CANCER INSTITUTE (NCI): - Integrated Subcellular Microscopy and ‘Omics in Cancer Cell Biology - Smart, Multi-Core Biopsy Needle. Digital Healthcare Platform to Reduce Financial Hardship for Cancer Patients - Digital Healthcare Platform to Reduce Financial Hardship for Cancer Patients - Leveraging Connected Health Technologies to Address and Improve Health Outcomes of Long-Term Cancer Survivors - Novel Approaches for Local Delivery of Chemopreventive Agents - Multiplexed Preclinical Tools for Longitudinal Characterization of Immunological Status in Tumor and its Microenvironment - In vitro Diagnostic for the Liver Flukes Opisthorchis viverrini and Clonorchis sinensis - Development of Artificial Intelligence (AI) Tools to Understand and Duplicate Experts Radiation Therapy Planning for Prostate Cancer - Clonogenic High-Throughput Assay for Screening Anti-Cancer Agents and Radiation Modulators - Drugs or Devices to Exploit the Immune Response Generated by Radiation Therapy - Clinical Trials of Systemic Targeted Radionuclide Therapies - Sensing Tools to Measure Biological Response to Radiotherapy - Combinatory Treatment Modalities Utilizing Radiation to Locally Activate or Release Systemically Delivered Therapeutics - Targeted Therapy for Cancer- and Cancer Therapy-Related Cachexia - Imaging for Cancer Immunotherapies NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI): - Active MRI Needle - Transcatheter Potts Shunt - Device System for Transcatheter Repair of Postinfarction Ventricular Septal Defect NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA): - A Wearable Alcohol Biosensor that Quantifies Blood Alcohol Concentration in Real Time - Data Science Tools for Alcohol Research NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID): - In Vivo Targeted Degradation of HIV Proteins - Particle-Based Delivery of HIV Env Immunogens - Co-Delivery and Formulation of Adjuvants for HIV Vaccines - Effective Targeted Delivery of RNA-based Vaccines and Therapeutics - Methods Improving HIV Protein Expression: Cell Substrate and Protein Purification - Reagents for Immunologic Analysis of Non-mammalian and Underrepresented Mammalian Models - B Cell Receptor and T Cell Receptor Repertoire Computational Tools - Development of Sample Sparing Assay - Adjuvant Discovery for Vaccines and for Autoimmune and Allergic Diseases - Adjuvant Development for Vaccines and for Autoimmune and Allergic Diseases - Mobile Health Point-of-Care Diagnostics - Development of POC Assays to Quantify anti-Tuberculosis Antibiotics in Blood - POC Diagnostic for Gonorrhea and Determination of Antimicrobial Susceptibility NATIONAL INSTITUTE ON DRUG ABUSE (NIDA): - DEA-Compliant Drug Detection and Deactivation Technology to Deter Opioid Theft in Hospitals for Next Generation Controlled Substance Diversion Prevention Program (CSDPP) - Leveraging Health IT Solutions to Combat Opioid Misuse. CENTER FOR DISEASE CONTROL AND PREVENTION (CDC) CENTER FOR GLOBAL HEALTH (CGH): - Multiplex Detection of Recent and Prior Exposure to Pathogens - Preservation of Supply Quality During Unmanned Aerial Vehicle (UAV) Transport - Improving Global Health with a Novel Handheld Counterfeit Drug Identifier NATIONAL CENTER FOR CHRONIC DISEASE AND HEALTH PROMOTION (NCCDPHP): - Community Based Worksite Wellness App Linking Employees to Wellness Resources - Objective Measurement of Opioid Withdrawal in Newborns NATIONAL CENTER FOR EMERGING ZOONOTIC AND INFECTIOUS DISEASE (NCEZID): - Novel Coatings/Surfaces on Indwelling Medical Devices to Prevent Biofilms NATIONAL CENTER FOR ENVIRONMENTAL HEALTH (NCEH): - Rapid Field Test to Improve Swimming Pool Water/Air Quality. OFFICE OF PUBLIC HEALTH PREPAREDNESS AND RESPONSE (OPHPR): - Rapid Test for Simultaneous Detection of Influenza (types A and B) and Streptococcus (Group A). NOTE - SBIR / STTR GRANT OPPORTUNITIES SBIR and STTR grant opportunities are also available for investigator-initiated ideas. Companies are encouraged to review omnibus SBIR/STTR grant solicitations of the National Institutes of Health, Centers for Disease Control and Prevention and Food and Drug Administration posted on the NIH SBIR/STTR funding web page located at https://sbir.nih.gov/funding#omni-sbir. Standard due dates for SBIR/STTR grant applications are September 5, 2018, January 7, 2019, and April 5, 2019. To understand better the differences between grants and contracts, see https://sbir.nih.gov/apply. For general information regarding the NIH/CDC SBIR Program, please refer to: Office of Extramural Programs, Office of Extramural Research, National Institutes of Health Phone 301-435-2688 sbir@od.nih.gov Contracting Office Address: Office of Acquisitions 5601 Fishers Lane 3rd Floor, MSC 9821 Bethesda, Maryland 20892 United States

Original Point of Contact

POC George W Kennedy, Phone: 240-669-5170, Tiffany Chadwick, Phone: 240-276-7293

Place of Performance

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