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Development and Maintenance of a Non-Human Primate Tissue Bank (NHP TB)

General Information

Document Type:PRESOL
Posted Date:Aug 30, 2017
Category: Research and Development
Set Aside:N/A

Contracting Office Address

Department of Health and Human Services, National Institutes of Health, National Institute on Mental Health, Contracts Management Branch, 6001 Executive Blvd, Rm 8154, MSC 9661, Bethesda, Maryland, 20892-9661

Description

The National Institute on Aging (NIA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) intends to re-compete requirements currently being performed under NIA Contract HHSN271201300018C. This procurement is being competed under full and open competitive procedures under NAICS 541990. It is anticipated that a single cost reimbursement type contract will be awarded for a one (1) year period of performance beginning on or about July 24, 2018, with four (4) option years. BACKGROUND: Basic biomedical research is supported by the NIA through several programs that require animal models of aging. These programs include genetics, immunology, endocrinology, pharmacology, neurobiology, organ-specific and system-wide physiology, behavior and nutrition. Aged NHPs are an important model for determining how research findings from experiments in lower organisms translate to human biology and aging. However, there are many drawbacks to using NHPs in research. The availability of NHPs is limited and rhesus macaques, the predominant NHP model in aging research, are particularly scarce. In recent years, an increasing number of rhesus monkeys have been used in AIDS research and vaccine and drug development, reducing the number of monkeys in the pipeline for the aging colonies. A second drawback is that NHPs are expensive to obtain and to house. Since rhesus monkeys live 30+ years and are not useful for aging research until they are close to 20 years old, a significant investment is made in every monkey used for aging research. And last but not least, there is strong public sentiment to reduce the number of NHPs used in biomedical research. From genetic, physiological and behavioral perspectives, NHP are our closest relatives in the animal world, and while that makes them so valuable to biomedical research it also makes their use in biomedical research a very sensitive issue. The Non-Human Primate Tissue Bank addresses all of these concerns. Investigators are able to make use of NHP biospecimens, thereby promoting investigations in a model closely related to humans. And by providing a mechanism for multiple investigators to share tissue from a single animal, more studies can be carried out with existing resources. n 2013, NIA awarded a five (5) year contract for the NHP TB and this Solicitation is for development of a new contract to continue this resource. OBJECTIVE: The objective of this contract is to provide a mechanism to archive and distribute excess tissue from non-human primates (NHP) that are being euthanized for research purposes. This will provide a new research resource to many investigators and contribute to a reduction in the number of NHP needed by the research community since multiple investigators will be able to take advantage of each animal. The tissue will allow investigators to test hypotheses in a model closely related to humans by providing access to NHP tissue without the expense of obtaining and housing the animals. This is an extremely important aspect of this project, as the supply of NHP in general, and rhesus macaques in particular, is very limited. The tissues will be collected under strictly controlled protocols to ensure the integrity of the tissue. Tissue will be flash-frozen without fixation or fixed and embedded, to fit the needs of a wide-range of molecular and histochemical techniques. PROJECT REQUIREMENTS: The primary requirements for this acquisition include: (A) Solicit tissue from sources identified by the Project Officer and tissue from sources identified by the Contractor through interactions with the research community, upon approval of the source by the Project Officer; (B) Coordinate the transfer of the tissue from a variety of institutions around the country to the Contractors facility, process and aliquot the tissue for preservation as needed, preserve the tissue and embed as needed, package, label and store the tissue, prepare a detailed inventory of the tissue; (C) Ship tissue to investigators at the direction of the Project Officer. The North American Industry Classification System (NAICS) Code will be 541990 with a standard size of $15 million. This proposed acquisition was previously publicized under sources sought notices HHS-NIH-NIDA(AG)-RDSS-17-026 and HHS-NIH-NIDA(AG)-SBSS-17-026. It is anticipated that the Solicitation/Request for Proposal will be posted on or about September 29, 2017. Contracting Office Address: NIMH/NIA Contracts Management Branch NIDA Neuroscience COAC 6001 Executive Blvd, Rm 8154, MSC 9661 Bethesda, Maryland 20892-9661 Primary Point of Contact.: Heather Orandi 6001 Executive Blvd, Rm 8154, MSC 9661 Bethesda, Maryland 20892-9661 Heather.Orandi@nih.gov

Original Point of Contact

POC Heather M. Orandi, Phone: 3014436162

Place of Performance

Address:
Rockville, Maryland, United States
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