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Light reception for non-image-forming visual functions in mice

General Information

Document Type:PRESOL
Posted Date:Aug 10, 2017
Category: Live Animals
Set Aside:N/A

Contracting Office Address

Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 6001 Executive Boulevard, Room 3165, Bethesda, Maryland, 20892, United States


INTRODUCTION PURSUANT TO FAR Subpart 5.2-Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT ACTION. THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Station Support Contracts and Simplified Acquisitions Branch (SS/SA) on behalf of the National Institute of Drug Abuse intends to negotiate and award a contract for a Light reception for non-image-forming visual functions in mice with John Hopkins University, 144 Mudd Hall, 3400 N. Charles Street, Baltimore, ME 21218 NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 541712 with a Size Standard of 1000 employees. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses of the Federal acquisition Requlation (FAR) in effect through the Federal Acquisition Circular (FAC) 05-95 and 95 January 19, 2017. STATUTORY AUTHORITY This acquisition is conducted as non-competitive under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302-1. This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source. DESCRIPTION OF REQUIREMENT Purpose and Objectives The purpose of this acquisition is to procure four (4) breeding pairs (eight mice in total) customized genetically manipulated mouse lines. These mouse lines are the essential tools on the mechanisms of circadian clock. These 4 lines are: Conditional Cre; Conditional melanopsin knockout; Conditional DTA; Strong DTA under Mel promoter. Project Description 1 male and 1 female mouse (4-8 weeks old) of each type below: 1.The Strong DTA under Mel promoter line is needed to kill ipRGCs (intrinsically photosensitive retinal ganglion cells) early in development to study their effects on physiological functions. 2.The Conditional Cre line is needed to label a subpopulation of ipRGCs at low number. This will give us a better resolution to look at each single cell and we can obtain more information. 3.The Conditional melanopsin line is to knockout the pigment in specified subtypes and at adult level. This will help us to learn the gene function with temporal and spacial specificities. 4.The Conditional DTA line is to kill ipRGCs with specific Cre lines and have subtype specificity. This will help us to learn the gene function in a defined cell population. 5.The breeding pairs must be received alive and in good health, as inspected by the vet in charge Period of Performance The delivery date has a lead time of 90 days after receipt of order. This shall be a fixed price contract. CLOSING STATEMENT This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice must include sufficient information to establish the interested parties bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. Respondents that believe that they are manufacturers or authorized resellers of the brand-name product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by August 21,2017, 12:00pm eastern standard time and must reference number HHS-NIH-NIDA-SSSA-PSOL-2017-414. Responses must be submitted electronically to Andrea McGee amcgee@nih.gov and must reference the solicitation number HHS-NIH-NIDA-SSSA-PSOL-2017-414 on your electronic request. FAX requests are not accepted. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."

Original Point of Contact

POC Andrea McGee, Phone: 301480-2449

Place of Performance

251 Bayview Blvd, Baltimore, Maryland, 21224, United States
Link: FBO.gov Permalink
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